Pseudomonas aeruginosa - a versatile human opportunistic pathogen.

About


I am currently a tenure-track research fellow at the University of Liverpool, Institute of Infection and Global Health.


My research interests revolve around understanding how pathogens cause disease. My main interests involve the opportunistic pathogen, Pseudomonas aeruginosa, and how it interacts with other species during infection. Deciphering these interactions could be key to both understanding the evolution of successful pathogens and the development of appropriate therapeutics. My research combines genomics, molecular microbiology and population studies combined with relevant infection models.




Publications

  • Fothergill JL, Neill DR, Loman N, Winstanley C, Kadioglu A. Pseudomonas aeruginosa adaptation in  the nasopharyngeal reservoir leads to migration and persistence in the lungs. Nat Commun. 2014 Sep 2;5:4780.
  • Neill DR, Saint GL, Bricio-Moreno L, Fothergill JL, Southern KW, Winstanley C, Christmas SE, Slupsky JR, McNamara PS, Kadioglu A, Flanagan BF. (2014). The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in the lungs of mice infected with Pseudomonas aeruginosa. PLoS One. 2014 May 21;9(5):e95892
  • Jeukens J, Boyle B, Kukavica-Ibrulj I, Ouellet MM, Aaron SD, Charette SJ, Fothergill JL, Tucker NP, Winstanley C and Levesque RC. (2014). Comparative Genomics of Isolates of a Pseudomonas aeruginosa Epidemic Strain Associated with Chronic Lung Infections of Cystic Fibrosis Patients. PLoS One. 2014 Feb 5;9(2):e87611.
  • Ashish A, Paterson S, Mowat E, Fothergill JL, WalshawMJ, Winstanley C (2013) Extensive diversification is a common feature of Pseudomonas aeruginosa populations during respiratory infections in cystic fibrosis. Journal of Cystic Fibrosis vol 12 pp 790-793
  • Wright EA, Fothergill JL, Paterson S, Brockhurst MA and Winstanley C (2013) Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium. BMC Microbiology vol 13 pp 170
  • Fothergill, J.L.*, Ledson, M.J., Walshaw, M.J., McNamara, P.S., Southern, K.W., and Winstanley, C. (2013) Comparison of real time diagnostic chemistries to detect Pseudomonas aeruginosa in respiratory samples from cystic fibrosis patients. Journal of Cystic Fibrosis
  • Fothergill JL, Ledson MJ, Walshaw MJ, McNamara PS, Southern KW and Winstanley C. (2013) Comparison of real time diagnostic chemistries to detect Pseudomonas aeruginosa in respiratory samples from cystic fibrosis patients.. Journal of Cystic Fibrosis
  • Kirchner, S., Fothergill, J.L., Wright E.A, James, C.E., Mowat, E. and Winstanley, C. (2012) Use of artificial sputum medium to test antibiotic efficacy against Pseudomonas aeruginosa in conditions more relevant to the cystic fibrosis lung. Journal of Visualized Experiments vol 64 pp e3857
  • Fothergill, J.L., Winstanley, C. and James, C.E. (2012) Novel therapeutic strategies to counter Pseudomonas aeruginosa infections. Expert Reviews of Anti-Infective Therapy vol 10 pp 219-235
  • James, C.E., Fothergill, J.L., Hall, A. J., Cottell, J., Kalwij, H., Brockhurst, M.A. and Winstanley, C. (2012) Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa. BMC Microbiology vol 12 pp 216
  • Fothergill JL and Winstanley C.. (2012) Emerging insights and therapies for human microbial disease. In: David Whitehouse, Ralph Rapley ed(s). Molecular and Cellular Therapeutics. Oxford, Wiley-Blackwell.
  • James C. E., Winstanley C. and Fothergill J. L. . (2012) Pseudomonas aeruginosa: Chronic Infections of the Cystic Fibrosis Lung.. In: Leo F. Delgado and Maria J. Vega. ed(s). Bacterial Infections: Characteristics, Types and Treatment. . New York, Novapublishers.
  • Fothergill, J.L., Walshaw, M.J. and Winstanley, C. (2012) Transmissible strains of Pseudomonas aeruginosa in cystic fibrosis lung infections. European Respiratory Journal vol 40 pp 227-238
  • Hall AJ, Fothergill JL, Kaye SB, Neal TJ, McNamara PS, Southern KW, Winstanley C. (2012) Intraclonal genetic diversity amongst cystic fibrosis and keratitis isolates of Pseudomonas aeruginosa. Journal of Medical Microbiology
  • Fothergill, J.L., Mowat, E., Walshaw, M.J., Ledson, M.J., James, C.E. and Winstanley, C. (2011) The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy vol 55 pp 426-428
  • Mowat, E., Paterson, S., Fothergill, J.L., Wright, E.A., Ledson, M.J., Walshaw, M.J., Brockhurst, M.A. and Winstanley, C. (2011) High phenotypic diversity and dynamic turnover in chronic Pseudomonas aeruginosa infections of cystic fibrosis patients. . American Journal of Respiratory and Critical Care Medicine vol 183 pp 1674-1679
  • Mohan, K., Lakshman, V., Fothergill, J.L., Ledson, M.J., Winstanley, C., Walshaw, M.J. (2010) Empyema due to a highly transmissible Pseudomonas aeruginosa strain in an adult cystic fibrosis patient. Journal of Medical Microbiology vol 59 pp 614-616
  • Fothergill, J.L., Mowat, E., Ledson, M.J., Walshaw, M.J., Winstanley, C. (2010) Fluctuations in phenotypes and genotypes within populations of Pseudomonas aeruginosa in the cystic fibrosis lung during pulmonary exacerbations. Journal of Medical Microbiology vol 59 pp 472-481
  • Fothergill, J.L, White, J., Foweraker, J.E., Walshaw, M.J., Ledson, M.J., Mahenthiralingam, E. and Winstanley, C. (2010) Impact of Pseudomonas aeruginosa genomic instability on the application of typing methods in chronic cystic fibrosis infections.. Journal of Clinical Microbiology vol 48 pp 2053-2059
  • (Jervis AJ), (Langdon R), (Hitchen P), (Lawson AJ), (Wood A), Fothergill JL, (Morris HR), (Dell A), (Wren B) and (Linton D). (2010) Characterization of N-linked protein glycosylation in Helicobacter pullorum. J Bacteriol vol 192 issue 19 pp 5228-5236
  • Carter, M., Fothergill, J.L., Walshaw, M.J., Rajakumar, K., Kadioglu, A. and Winstanley, C. (2010) A sub-type of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection.. Journal of Infectious Diseases vol 202 pp 935-942
  • Winstanley C. & Fothergill J.L. (2009) The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiology Letters vol 290 pp 1-9
  • Winstanley, C., Langille, M.G.I., Fothergill, J.L., Kukavica-Ibrulj, I., Paradis-Bleau, C., Sanschagrin, F., Thompson, N.R., Winsor, G.L., Quail, M.A., Lennard, N., Bignell, A., Clarke, L., Seeger, K., Saunders, D., Harris, D., Parkhill, J., Hancock, R.E.W.*, Brinkman, F.S.L. and Levesque, R.C. (2009) Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Research vol 19 issue 1 pp 12-23
  • Fothergill, J.L, Upton, A., Pitt, T.L., Hart, C.A. and Winstanley, C. (2008) Diagnostic multiplex PCR assay for the identification of the Liverpool, Midlands 1 and Manchester epidemic strains of Pseudomonas aeruginosa.. Journal of Cystic Fibrosis
  • Mohan, K., Fothergill, J. L. Storrar, J., Ledson, M.J., Winstanley, C., Walshaw, M.J. (2008) Transmission of a of Pseudomonas aeruginosa epidemic strain from a cystic fibrosis patient to a pet cat.. Thorax vol 63 pp 839-840
  • Fothergill, J.L., Panagea, S., Hart, C.A., Walshaw, M.J., Pitt, T.L. and Winstanley, C. (2007) Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain.. BMC Microbiology vol 7 pp 45
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